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Little-known outside Japan, Shizuoka Prefecture hugs the coast to the south of Mount Fuji. Home to the Tokyo getaway of Izu, the prefecture is known as the starting point for three of the main ...

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The distinguishing viewpoint of this treatise is an examination of AKT in the myocardial context by integrating a plethora of observations into a coherent perspective that will clarify how and why AKT has attained both celebrity and notoriety as a seemingly omnipresent node at …

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One aspect of the present invention relates to heterocyclic compounds comprising a sulfonamide moiety. A second aspect of the present invention relates to the use of the heterocyclic compounds comprising a sulfonamide moiety to treat diseases, afflictions or maladies caused at least in part by abnormal activity of one or more GPCRs or ligand-gated ion channels.

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Save. Martin Gainor (March 27, 1915 – December 29, 1959) was a Canadian football player who played for the Winnipeg Blue Bombers.He won the Grey Cup with them in 1939. He is a member of the Blue Bombers Hall of Fame. [1] [2] [3]

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g Groschen.One hundredth of an Austrian Schilling from 1823 until the euro was introduced. Preceding that, the Groschen has a long if not always lustrous history; I don't plan to research when in the past it has and has not been abbreviated by a lower-case letter gee. The word Groschen continues in use in proverbial expressions in Germany as well as Austria.

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Once the TSC2/TSC1 complex is dissociated, phosphorylated TSC2 activates the GTP form of Rheb, thereby allowing Rheb to directly bind to and activate mTOR (414, 429, 626, 693). Signaling through PI3K-AKT-TSC1/2-Rheb was considered to be the main avenue through which most activating stimuli are transduced to mTOR.

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